1 Ocak 2021 Dergi makalesi Açık Erişim

Dogan, Soner; Cicekdal, Munevver B.; Ozorhan, Umit; Karabiyik, Goktug; Kazan, Busra T.; Ekici, Isin D.; Yilmaz, Bayram; Demirel, Pinar B.; Coban, Ilker; Tuysuz, Emre Can; Kuskucu, Aysegul; Bayrak, Omer F.; Cleary, Margot P.; Tuna, Bilge G.

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    "creators": [
      {
        "affiliation": "Yeditepe Univ, Dept Med Biol, Sch Med, Istanbul, Turkey", 
        "name": "Dogan, Soner"
      }, 
      {
        "name": "Cicekdal, Munevver B."
      }, 
      {
        "affiliation": "Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Lubeck, Germany", 
        "name": "Ozorhan, Umit"
      }, 
      {
        "affiliation": "Yeditepe Univ, Dept Biophys, Sch Med, Istanbul, Turkey", 
        "name": "Karabiyik, Goktug"
      }, 
      {
        "affiliation": "Yeditepe Univ, Dept Med Biol, Sch Med, Istanbul, Turkey", 
        "name": "Kazan, Busra T."
      }, 
      {
        "affiliation": "Yeditepe Univ, Dept Pathol, Sch Med, Istanbul, Turkey", 
        "name": "Ekici, Isin D."
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      {
        "affiliation": "Yeditepe Univ, Dept Physiol, Sch Med, Istanbul, Turkey", 
        "name": "Yilmaz, Bayram"
      }, 
      {
        "affiliation": "Maltepe Univ, Dept Med Biol & Genet, Sch Med, Istanbul, Turkey", 
        "name": "Demirel, Pinar B."
      }, 
      {
        "affiliation": "Yeditepe Univ, Dept Med Biol, Sch Med, Istanbul, Turkey", 
        "name": "Coban, Ilker"
      }, 
      {
        "affiliation": "Lund Univ, Dept Translat Med, Lund, Sweden", 
        "name": "Tuysuz, Emre Can"
      }, 
      {
        "affiliation": "Yeditepe Univ, Dept Genet, Sch Med, Istanbul, Turkey", 
        "name": "Kuskucu, Aysegul"
      }, 
      {
        "affiliation": "Yeditepe Univ, Dept Genet, Sch Med, Istanbul, Turkey", 
        "name": "Bayrak, Omer F."
      }, 
      {
        "affiliation": "Univ Minnesota, Hormel Inst, Med Res Ctr, 801 16th Ave NE, Austin, MN 55912 USA", 
        "name": "Cleary, Margot P."
      }, 
      {
        "affiliation": "Yeditepe Univ, Dept Biophys, Sch Med, Istanbul, Turkey", 
        "name": "Tuna, Bilge G."
      }
    ], 
    "description": "Calorie restriction (CR) is suggested to prevent the development of mammary tumors (MTs); however, the mechanism remains to be clarified. We aimed to determine the microRNA (miRNA) profile in mice applied to 2 different CR protocols; chronic (CCR) and intermittent (ICR) and follow the MT development. In addition, the roles of miRNAs involved in adiponectin and/or leptin signaling pathways were investigated. Mice were divided into 3 groups: ad-libitum (AL), CCR, or ICR, which comprised 3 weeks of AL feeding followed by I week of 60% CR in a cyclic manner. Blood and tissue collection were performed at weeks 10,17/18, 49/50 and 81/82. Long-term CCR provided better protection compared with ICR for MT development with a delay in the MT occurrence. Adiponectin expression in mammary fat pad were significantly higher in CCR group compared with AL. Using GeneChip Array, 250 of 3195 miRNAs were differentially expressed among the dietary groups. Thirteen of 250 miRNAs were related to adiponectin and/or leptin signaling genes. Results were verified by reverse transcription polymerase chain reaction. Specifically, miR-326-3p, miR-500-3p and miR-129-5p, which are related to adiponectin and/or leptin signaling, may play important roles in the preventive effects of CR in MT development and in ageing. Thus, these miRNAs might be putative biomarkers to target for diagnostic and treatment purposes.", 
    "doi": "10.1139/apnm-2020-1000", 
    "has_grant": false, 
    "journal": {
      "issue": "8", 
      "pages": "866-876", 
      "title": "APPLIED PHYSIOLOGY NUTRITION AND METABOLISM", 
      "volume": "46"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2021-01-01", 
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      "title": "Dergi makalesi", 
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    "science_branches": [
      "Di\u011fer"
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    "title": "Roles of adiponectin and leptin signaling-related microRNAs in the preventive effects of calorie restriction in mammary tumor development"
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