1 Ocak 2021 Dergi makalesi Açık Erişim

Unal, Mehmet Altay; Bayrakdar, Fatma; Fusco, Laura; Besbinar, Omur; Shuck, Christopher E.; Yalcin, Suleyman; Erken, Mine Turktas; Ozkul, Aykut; Gurcan, Cansu; Panatli, Oguzhan; Summak, Gokce Yagmur; Gokce, Cemile; Orecchioni, Marco; Gazzi, Arianna; Vitale, Flavia; Somers, Julia; Demir, Emek; Yildiz, Serap Suzuk; Nazir, Hasan; Grivel, Jean-Charles; Grivel, Jean-Charles

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/230128</identifier>
  <creators>
    <creator>
      <creatorName>Unal, Mehmet Altay</creatorName>
      <givenName>Mehmet Altay</givenName>
      <familyName>Unal</familyName>
      <affiliation>Ankara Univ, Stem Cell Inst, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bayrakdar, Fatma</creatorName>
      <givenName>Fatma</givenName>
      <familyName>Bayrakdar</familyName>
      <affiliation>Minist Hlth, Microbiol References Lab, Gen Directorate Publ Hlth, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Fusco, Laura</creatorName>
      <givenName>Laura</givenName>
      <familyName>Fusco</familyName>
    </creator>
    <creator>
      <creatorName>Besbinar, Omur</creatorName>
      <givenName>Omur</givenName>
      <familyName>Besbinar</familyName>
    </creator>
    <creator>
      <creatorName>Shuck, Christopher E.</creatorName>
      <givenName>Christopher E.</givenName>
      <familyName>Shuck</familyName>
    </creator>
    <creator>
      <creatorName>Yalcin, Suleyman</creatorName>
      <givenName>Suleyman</givenName>
      <familyName>Yalcin</familyName>
      <affiliation>Minist Hlth, Microbiol References Lab, Gen Directorate Publ Hlth, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erken, Mine Turktas</creatorName>
      <givenName>Mine Turktas</givenName>
      <familyName>Erken</familyName>
      <affiliation>Gazi Univ, Dept Biol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkul, Aykut</creatorName>
      <givenName>Aykut</givenName>
      <familyName>Ozkul</familyName>
    </creator>
    <creator>
      <creatorName>Gurcan, Cansu</creatorName>
      <givenName>Cansu</givenName>
      <familyName>Gurcan</familyName>
    </creator>
    <creator>
      <creatorName>Panatli, Oguzhan</creatorName>
      <givenName>Oguzhan</givenName>
      <familyName>Panatli</familyName>
      <affiliation>Ankara Univ, Dept Biomed Engn, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Summak, Gokce Yagmur</creatorName>
      <givenName>Gokce Yagmur</givenName>
      <familyName>Summak</familyName>
      <affiliation>Ankara Univ, Stem Cell Inst, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gokce, Cemile</creatorName>
      <givenName>Cemile</givenName>
      <familyName>Gokce</familyName>
      <affiliation>Ankara Univ, Dept Biomed Engn, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Orecchioni, Marco</creatorName>
      <givenName>Marco</givenName>
      <familyName>Orecchioni</familyName>
      <affiliation>La Jolla Inst Immunol, La Jolla, CA USA</affiliation>
    </creator>
    <creator>
      <creatorName>Gazzi, Arianna</creatorName>
      <givenName>Arianna</givenName>
      <familyName>Gazzi</familyName>
    </creator>
    <creator>
      <creatorName>Vitale, Flavia</creatorName>
      <givenName>Flavia</givenName>
      <familyName>Vitale</familyName>
      <affiliation>Univ Penn, Ctr Neuroengn &amp; Therapeut, Dept Neurol Bioengn Phys Med &amp; Rehabil, Philadelphia, PA 19104 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Somers, Julia</creatorName>
      <givenName>Julia</givenName>
      <familyName>Somers</familyName>
      <affiliation>Oregon Hlth &amp; Sci Univ, Dept Mol &amp; Med Genet, Portland, OR 97201 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Demir, Emek</creatorName>
      <givenName>Emek</givenName>
      <familyName>Demir</familyName>
      <affiliation>Oregon Hlth &amp; Sci Univ, Dept Mol &amp; Med Genet, Portland, OR 97201 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Yildiz, Serap Suzuk</creatorName>
      <givenName>Serap Suzuk</givenName>
      <familyName>Yildiz</familyName>
      <affiliation>Minist Hlth, Microbiol References Lab, Gen Directorate Publ Hlth, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nazir, Hasan</creatorName>
      <givenName>Hasan</givenName>
      <familyName>Nazir</familyName>
      <affiliation>Ankara Univ, Dept Chem, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Grivel, Jean-Charles</creatorName>
      <givenName>Jean-Charles</givenName>
      <familyName>Grivel</familyName>
      <affiliation>Sidra Med, Deep Phenotyping Core, Doha, Qatar</affiliation>
    </creator>
    <creator>
      <creatorName>Grivel, Jean-Charles</creatorName>
      <givenName>Jean-Charles</givenName>
      <familyName>Grivel</familyName>
      <affiliation>Sidra Med, Deep Phenotyping Core, Doha, Qatar</affiliation>
    </creator>
  </creators>
  <titles>
    <title>2D Mxenes With Antiviral And Immunomodulatory Properties: A Pilot Study Against Sars-Cov-2</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/230128</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.nantod.2021.101136</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Two-dimensional transition metal carbides/carbonitrides known as MXenes are rapidly growing as multimodal nanoplatforms in biomedicine. Here, taking SARS-CoV-2 as a model, we explored the antiviral properties and immune-profile of a large panel of four highly stable and well-characterized MXenes Ti3C2Tx, Ta4C3Tx, Mo2Ti2C3Tx and Nb4C3Tx. To start with antiviral assessment, we first selected and deeply analyzed four different SARS-CoV-2 genotypes, common in most countries and carrying the wild type or mutated spike protein. When inhibition of the viral infection was tested in vitro with four viral clades, Ti3C2Tx in particular, was able to significantly reduce infection only in SARS-CoV-2/clade GR infected Vero E6 cells. This difference in the antiviral activity, among the four viral particles tested, highlights the importance of considering the viral genotypes and mutations while testing antiviral activity of potential drugs and nanomaterials. Among the other MXenes tested, Mo2Ti2C3Tx also showed antiviral properties. Proteomic, functional annotation analysis , comparison to the already published SARS-CoV-2 protein interaction map revealed that MXene-treatment exerts specific inhibitory mechanisms. Envisaging future antiviral MXene-based drug nano-formulations and considering the central importance of the immune response to viral infections, the immune impact of MXenes was evaluated on human primary immune cells by flow cytometry and single-cell mass cytometry on 17 distinct immune subpopulations. Moreover, 40 secreted cytokines were analyzed by Luminex technology. MXene immune profiling revealed i) the ex-cellent bio and immune compatibility of the material, as well as the ability of MXene ii) to inhibit mono-cytes and iii) to reduce the release of pro-inflammatory cytokines, suggesting an anti-inflammatory effect elicited by MXene. We here report a selection of MXenes and viral SARS-CoV-2 genotypes/mutations, a series of the computational, structural and molecular data depicting deeply the SARS-CoV-2 mechanism of inhibition, as well as high dimensional single-cell immune-MXene profiling. Taken together, our results provide a compendium of knowledge for new developments of MXene-based multi-functioning nanosys-tems as antivirals and immune-modulators.</description>
  </descriptions>
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