1 Ocak 2011 Dergi makalesi Açık Erişim

Cokol, Murat; Chua, Hon Nian; Tasan, Murat; Mutlu, Beste; Weinstein, Zohar B.; Suzuki, Yo; Nergiz, Mehmet E.; Costanzo, Michael; Baryshnikova, Anastasia; Giaever, Guri; Nislow, Corey; Myers, Chad L.; Andrews, Brenda J.; Boone, Charles; Roth, Frederick P.

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        "name": "Cokol, Murat"
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      {
        "name": "Chua, Hon Nian"
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      {
        "name": "Tasan, Murat"
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        "affiliation": "Sabanci Univ, Biol Sci & Bioengn Program, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey", 
        "name": "Mutlu, Beste"
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      {
        "affiliation": "Sabanci Univ, Biol Sci & Bioengn Program, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey", 
        "name": "Weinstein, Zohar B."
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      {
        "name": "Suzuki, Yo"
      }, 
      {
        "affiliation": "Zirve Univ, Dept Comp Engn, Fac Engn, Gaziantep, Turkey", 
        "name": "Nergiz, Mehmet E."
      }, 
      {
        "affiliation": "Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada", 
        "name": "Costanzo, Michael"
      }, 
      {
        "affiliation": "Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada", 
        "name": "Baryshnikova, Anastasia"
      }, 
      {
        "name": "Giaever, Guri"
      }, 
      {
        "name": "Nislow, Corey"
      }, 
      {
        "affiliation": "Univ Minnesota Twin Cities, Dept Comp Sci & Engn, Minneapolis, MN USA", 
        "name": "Myers, Chad L."
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      {
        "name": "Andrews, Brenda J."
      }, 
      {
        "name": "Boone, Charles"
      }, 
      {
        "name": "Roth, Frederick P."
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    "description": "Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs target the products of genes that act in parallel pathways ('specific synergy'). Such cases of drug synergy should tend to correspond to synergistic genetic interaction between the corresponding target genes. Alternatively, 'promiscuous synergy' can arise when one drug non-specifically increases the effects of many other drugs, for example, by increased bioavailability. To assess the relative abundance of these drug synergy types, we examined 200 pairs of antifungal drugs in S. cerevisiae. We found 38 antifungal synergies, 37 of which were novel. While 14 cases of drug synergy corresponded to genetic interaction, 92% of the synergies we discovered involved only six frequently synergistic drugs. Although promiscuity of four drugs can be explained under the bioavailability model, the promiscuity of Tacrolimus and Pentamidine was completely unexpected. While many drug synergies correspond to genetic interactions, the majority of drug synergies appear to result from non-specific promiscuous synergy. Molecular Systems Biology 7: 544; published online 8 November 2011; doi:10.1038/msb.2011.71", 
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      "title": "MOLECULAR SYSTEMS BIOLOGY", 
      "volume": "7"
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    "publication_date": "2011-01-01", 
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      "title": "Dergi makalesi", 
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    "title": "Systematic exploration of synergistic drug pairs"
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