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Novel approaches for COVID-19 diagnosis and treatment: a nonsystematic review

Şebnem; Hakan; Mehmet Dinçer; Feride


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    <subfield code="a">&lt;p&gt;Since COVID-19 pandemic has been continuously rising and spreading, several original contributions and review articles&amp;nbsp;on COVID-19 started to appear in the literature. The review articles are mainly focus on the current status of the pandemic along&amp;nbsp;with current status of the corona diagnosis and treatment process. Due to some disadvantages of the currently used methods, the&amp;nbsp;improvement on the novel promising diagnosis and treatment methods of corona virus is very important issue. In this review, after briefly&amp;nbsp;discussing the status of current diagnosis and treatment methods, we present to the scientific community, novel promising methods&amp;nbsp;in the diagnosis and treatment of COVID-19. As with other novel approaches, first, the diagnosis potential of mass spectroscopy and&amp;nbsp;optical spectroscopic methods such as UV/visible, infrared, and Raman spectroscopy coupled with chemometrics will be discussed&amp;nbsp;for the corona virus infected samples based on the relevant literature. In vibrational spectroscopy studies, due to complexity of the&amp;nbsp;data, multivariate analysis methods are also applied to data. The application of multivariate analysis tools that can be used to extract&amp;nbsp;useful information from the data for diagnostic and characterisation purposes is also included in this review. The reviewed methods&amp;nbsp;include hierarchical cluster analysis, principal component analysis, linear and quadratic discriminant analysis, support vector machine&amp;nbsp;algorithm, and one form of neural networks namely deep learning method. Second, novel treatment methods such as photodynamic&amp;nbsp;therapy and the use of nanoparticles in the in-corona virus therapy will be discussed. Finally, the advantages of novel promising diagnosis&amp;nbsp;and treatment methods in COVID-19, over standard methods will be discussed. One of the main aims of this paper is to encourage the&amp;nbsp;scientific community to explore the potential of this novel tools for their use in corona virus characterization, diagnosis, and treatment.&lt;/p&gt;</subfield>
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