1 Ocak 2011 Dergi makalesi Açık Erişim

Torul, Hilal; Tamer, Ugur

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/21903</identifier>
  <creators>
    <creator>
      <creatorName>Torul, Hilal</creatorName>
      <givenName>Hilal</givenName>
      <familyName>Torul</familyName>
      <affiliation>Gazi Univ, Dept Analyt Chem, Fac Pharm, TR-06330 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tamer, Ugur</creatorName>
      <givenName>Ugur</givenName>
      <familyName>Tamer</familyName>
      <affiliation>Gazi Univ, Dept Analyt Chem, Fac Pharm, TR-06330 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Determination Of Enantiomers Of Atenolol And Propranolol In Pharmaceutical Formulations By Hplc</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2011</publicationYear>
  <dates>
    <date dateType="Issued">2011-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/21903</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.81043/aperta.21902</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.81043/aperta.21903</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
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  <descriptions>
    <description descriptionType="Abstract">A validated HPLC-UV method was developed for the determination of R(-), S(+)-atenolol and R(-), S(+)-propranolol in pharmaceutical formulations. The proposed method required no elaborate sample preparation and was found to be selective, linear, and repeatable within the established ranges. Atenolol and propranolol isomers were separated using a Chirex 3022 (S) column with the mobile phases hexane-dichloromethane-methanol-trifluoroacetic acid (35+35+5+0.25, v/v/v/v) and hexane-dichloromethane-ethanol-trifluoroacetic acid (55+40+5+0.25, v/v/v/v), respectively. The LOD values of R(-) and S(+)-atenolol were 12.3 and 9.86 mu g/mL, respectively, and 0.61 and 0.89 mu g/mL, respectively, for R(-) and S(+)-propranolol. Retention times of R(-)-propranolol and S(+)-propranolol were 12.4 and 14.3 min, respectively, and 29.06 and 32.71 min, respectively, for (R)-atenolol and (S)-atenolol. The proposed method was applied to the determination of enantiomers in pharmaceutical formulations, and no interference from any excipients was found.</description>
  </descriptions>
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