1 Ocak 2011 Dergi makalesi Açık Erişim

Alicikus, Zumre A.; Yamada, Yoshiya; Zhang, Zhigang; Pei, Xin; Hunt, Margie; Kollmeier, Marisa; Cox, Brett; Zelefsky, Michael J.

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{
  "DOI": "10.1002/cncr.25467", 
  "abstract": "BACKGROUND. The authors investigated long-term tumor control and toxicity outcomes after high-dose, intensity-modulated radiation therapy (IMRT) in patients who had clinically localized prostate cancer. METHODS. Between April 1996 and January 1998, 170 patients received 81 gray (Gy) using a 5-field IMRT technique. Patients were classified according to the National Comprehensive Cancer Network-defined risk groups. Toxicity data were scored according to the Common Terminology Criteria for Adverse Events Version 3.0. Freedom from biochemical relapse, distant metastases, and cause-specific survival outcomes were calculated. The median follow-up was 99 months. RESULTS. The 10-year actuarial prostate-specific antigen relapse-free survival rates were 81% for the low-risk group, 78% for the intermediate-risk group, and 62% for the high-risk group; the 10-year distant metastases-free rates were 100%, 94%, and 90%, respectively; and the 10-year cause-specific mortality rates were 0%, 3%, and 14%, respectively. The 10-year likelihood of developing grade 2 and 3 late genitourinary toxicity was 11% and 5%, respectively; and the 10-year likelihood of developing grade 2 and 3 late gastrointestinal toxicity was 2% and 1%, respectively. No grade 4 toxicities were observed. CONCLUSIONS. To the authors' knowledge, this report represents the longest followed cohort of patients who received high-dose radiation levels of 81 Gy using IMRT for localized prostate cancer. The findings indicated that high-dose IMRT is well tolerated and is associated with excellent long-term tumor-control outcomes in patients with localized prostate cancer Cancer 2011; 117: 1429-37. (C) 2010 American Cancer Society.", 
  "author": [
    {
      "family": "Alicikus", 
      "given": " Zumre A."
    }, 
    {
      "family": "Yamada", 
      "given": " Yoshiya"
    }, 
    {
      "family": "Zhang", 
      "given": " Zhigang"
    }, 
    {
      "family": "Pei", 
      "given": " Xin"
    }, 
    {
      "family": "Hunt", 
      "given": " Margie"
    }, 
    {
      "family": "Kollmeier", 
      "given": " Marisa"
    }, 
    {
      "family": "Cox", 
      "given": " Brett"
    }, 
    {
      "family": "Zelefsky", 
      "given": " Michael J."
    }
  ], 
  "container_title": "CANCER", 
  "id": "21197", 
  "issue": "7", 
  "issued": {
    "date-parts": [
      [
        2011, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1429-1437", 
  "title": "Ten-Year Outcomes of High-Dose, Intensity-Modulated Radiotherapy for Localized Prostate Cancer", 
  "type": "article-journal", 
  "volume": "117"
}