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A microfluidic based differential plasmon resonance sensor

2011    Okan, Melih; Balci, Osman; Kocabas, Coskun

A new type of differential surface plasmon (SPR) sensor integrated with a microfluidic system is presented. The working principle of the microfluidic device is based on hydrodynamic modulation of two laminar streams inside a microchannel to provide periodic changes of the environment on the SPR sensor. The modulated reflectance is then demodulated using a lock-in amplifier. The presented sensor provides sensitivities of index of refraction about 4 x 10(-8) RIU together with a 4 orders of magnitude dynamic range. This method demonstrates a sensitive detection scheme which could be used for label-free detection. (C) 2011 Elsevier B.V. All rights reserved.