1 Ocak 2011 Dergi makalesi Açık Erişim

Ergen, Arzu; Isbir, Selim; Timirci, Ozlem; Tekeli, Atike; Isbir, Turgay

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/19807</identifier>
  <creators>
    <creator>
      <creatorName>Ergen, Arzu</creatorName>
      <givenName>Arzu</givenName>
      <familyName>Ergen</familyName>
      <affiliation>Istanbul Univ, Inst Expt Med, Dept Mol Med, TR-34280 Capa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Isbir, Selim</creatorName>
      <givenName>Selim</givenName>
      <familyName>Isbir</familyName>
      <affiliation>Univ Marmara, Fac Med, Dept Cardiovasc Surg, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Timirci, Ozlem</creatorName>
      <givenName>Ozlem</givenName>
      <familyName>Timirci</familyName>
      <affiliation>Istanbul Univ, Inst Expt Med, Dept Mol Med, TR-34280 Capa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekeli, Atike</creatorName>
      <givenName>Atike</givenName>
      <familyName>Tekeli</familyName>
      <affiliation>Uskudar State Hosp, Clin Cardiovasc Surg, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Isbir, Turgay</creatorName>
      <givenName>Turgay</givenName>
      <familyName>Isbir</familyName>
      <affiliation>Yeditepe Univ, Dept Med Biol, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Effects Of Myeloperoxidase-463 G/A Gene Polymorphism And Plasma Levels On Coronary Artery Disease</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2011</publicationYear>
  <dates>
    <date dateType="Issued">2011-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/19807</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11033-010-0181-4</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Myeloperoxidase is a lysosomal enzyme of polymorphonuclear leucocytes that contributes to inflamatory responses. In previous studies it was shown that MPO was synthesized in atherosclerotic lesions responsible of lipoprotein oxidations. We aimed to determine the MPO -463 G/A gene polymorphism distribution in Turkish population and evaluate the effects of it on myeloperoxidase levels. There were 100 myocardial infarct patients and 100 healthy control subjects in our study. MPO polymorphism was studied by using PCR-RFLP technique and MPO levels were measured by ELISA. It was shown that MPO levels were increasing in patients after myocardial infarct event but there were no effect of MPO -463 G/A polymorphism on MPO levels. It was also found that serum total cholesterol and LDL-cholesterol levels and smoking was contributing factors in increments of MPO enzymes. We observed that MPO levels were increased in CAD but there were no effect of MPO -463 G/A polymorphism on MPO levels.</description>
  </descriptions>
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