1 Ocak 2011 Dergi makalesi Açık Erişim

Akalin, Ibrahim; Koca, Ebru; Karabulut, Halil G.; Haznedaroglu, Ibrahim C.; Cetiner, Deniz; Hayran, Mutlu; Onal, Ibrahim K.; Ozcebe, Osman I.; Tukun, Ajlan

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        "affiliation": "Ankara Univ, Fac Med, Dept Med Genet, TR-06100 Ankara, Turkey", 
        "name": "Akalin, Ibrahim"
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      {
        "affiliation": "Ankara Univ, Fac Med, Dept Internal Med, Hematol Unit, TR-06100 Ankara, Turkey", 
        "name": "Koca, Ebru"
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      {
        "affiliation": "Ankara Univ, Fac Med, Dept Med Genet, TR-06100 Ankara, Turkey", 
        "name": "Karabulut, Halil G."
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      {
        "affiliation": "Ankara Univ, Fac Med, Dept Internal Med, Hematol Unit, TR-06100 Ankara, Turkey", 
        "name": "Haznedaroglu, Ibrahim C."
      }, 
      {
        "affiliation": "Ankara Univ, Fac Med, Dept Internal Med, Hematol Unit, TR-06100 Ankara, Turkey", 
        "name": "Cetiner, Deniz"
      }, 
      {
        "affiliation": "Ankara Univ, Fac Med, Dept Prevent Oncol, TR-06100 Ankara, Turkey", 
        "name": "Hayran, Mutlu"
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Med, Dept Internal Med, TR-06100 Ankara, Turkey", 
        "name": "Onal, Ibrahim K."
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      {
        "affiliation": "Ankara Univ, Fac Med, Dept Internal Med, Hematol Unit, TR-06100 Ankara, Turkey", 
        "name": "Ozcebe, Osman I."
      }, 
      {
        "affiliation": "Ankara Univ, Fac Med, Dept Med Genet, TR-06100 Ankara, Turkey", 
        "name": "Tukun, Ajlan"
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    "description": "Local bone marrow renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin converting enzyme (ACE) converts angiotensinogen-I to its physiologically active peptide angiotensinII, which stimulates proliferation and differentiation of hematopoietic stem cells through angiotensin II type 1 receptors. We investigated the ACE insertion/deletion (I/D) gene polymorphisms in patients with hematological malignancies including acute and chronic leukemia, myelodysplastic syndrome and multiple myeloma. Our results showed that 80.4% of the patients represented ID/II genotype, whereas it was 55.9% of the control group and 3.2 fold increased disease risk in the existence of insertion allele (ID/II). This is the first study demonstrating possible effects of ACE I/D gene polymorphism of the local bone marrow RAS components on leukemic hematopoiesis.", 
    "doi": "10.4999/uhod.09164", 
    "has_grant": false, 
    "journal": {
      "issue": "1", 
      "pages": "1-9", 
      "title": "UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI", 
      "volume": "21"
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    "publication_date": "2011-01-01", 
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    "resource_type": {
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      "title": "Dergi makalesi", 
      "type": "publication"
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    "title": "Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Leukemic Hematopoiesis"
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