1 Ocak 2013 Dergi makalesi Açık Erişim

Olgen, Sureyya; Bakar, Filiz; Aydin, Semra; Nebioglu, Dogu; Nebioglu, Serpil

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/16017</identifier>
  <creators>
    <creator>
      <creatorName>Olgen, Sureyya</creatorName>
      <givenName>Sureyya</givenName>
      <familyName>Olgen</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bakar, Filiz</creatorName>
      <givenName>Filiz</givenName>
      <familyName>Bakar</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aydin, Semra</creatorName>
      <givenName>Semra</givenName>
      <familyName>Aydin</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nebioglu, Dogu</creatorName>
      <givenName>Dogu</givenName>
      <familyName>Nebioglu</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nebioglu, Serpil</creatorName>
      <givenName>Serpil</givenName>
      <familyName>Nebioglu</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis Of New Indole-2-Carboxamide And 3-Acetamide Derivatives And Evaluation Their Antioxidant Properties</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/16017</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3109/14756366.2011.631183</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In recent years, antioxidant compounds play an important role as a health-protecting factor. Antioxidants protect cells against the damaging effects of reactive oxygen species (ROS). An imbalance between antioxidants and ROS results in oxidative stress, which leads to cellular damage and it is linked to many vital diseases. It was shown that heme oxygenase (HO) provides efficient cytoprotection against oxidative stress. In this study, a series of indole-2-carboxamide and 3-acetamide derivatives was tested for in vitro effects on HO activity and 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition. Among the synthesized compounds, N-[3-(dimethylamino)propyl]-1H-indole-2-carboxamide 3 was found as the most activator of HO and N-(2-(dimethylamino)ethyl)-2-(1H-indol-3-yl)acetamide 8 was found the most potent inhibitor for DPPH at 10(-4) M concentration.</description>
  </descriptions>
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