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From Invisible Structures of SWCNTs toward Fluorescent and Targeting Architectures for Cell Imaging

Ag, Didem; Seleci, Muharrem; Bongartz, Rebecca; Can, Mustafa; Yurteri, Seda; Cianga, Ioan; Stahl, Frank; Timur, Suna; Scheper, Thomas; Yagci, Yusuf


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        "affiliation": "Ege Univ, Fac Sci, Dept Biochem, TR-35100 Bornova, Turkey", 
        "name": "Ag, Didem"
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        "affiliation": "Ege Univ, Fac Sci, Dept Biochem, TR-35100 Bornova, Turkey", 
        "name": "Seleci, Muharrem"
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      {
        "affiliation": "Leibniz Univ Hannover, Inst Tech Chem, D-30167 Hannover, Germany", 
        "name": "Bongartz, Rebecca"
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      {
        "affiliation": "Katip Celebi Izmir Univ, Fac Engn & Architecture, TR-35620 Balatcik Izmir, Turkey", 
        "name": "Can, Mustafa"
      }, 
      {
        "affiliation": "Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey", 
        "name": "Yurteri, Seda"
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      {
        "name": "Cianga, Ioan"
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      {
        "affiliation": "Leibniz Univ Hannover, Inst Tech Chem, D-30167 Hannover, Germany", 
        "name": "Stahl, Frank"
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      {
        "affiliation": "Ege Univ, Fac Sci, Dept Biochem, TR-35100 Bornova, Turkey", 
        "name": "Timur, Suna"
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      {
        "affiliation": "Leibniz Univ Hannover, Inst Tech Chem, D-30167 Hannover, Germany", 
        "name": "Scheper, Thomas"
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        "name": "Yagci, Yusuf"
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    "description": "Single-walled carbon nanotubes (SWNTs) are unique nanostructures used as cargo systems for variety of diagnostic and therapeutic agents. For taking advantage of these structures in biological processes, they should be visible. Therefore, fluorescence labeling of SWCNTs with various probes is a significant issue. Herein, we demonstrate a simple approach for cell specific imaging and diagnosis by combining SWCNTs with a copolymer poly(para-epsilon-caprolactone) (PCL) side chains (PPP-g-PSt-PCL). In this approach PPP-g-PSt-PCL is noncovalently attached on carboxyl functional SWCNTs. The obtained fluorescent probe is bound to folic acid (FA) for targeted imaging of folate receptor (FR) positive HeLa cells. In vitro studies demonstrate that this conjugate can specifically bind to HeLa cells and indicate great potential for targeting and imaging studies.", 
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