1 Ocak 2013 Dergi makalesi Açık Erişim

Heath, Paul R.; Kirby, Janine; Shaw, Pamela J.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/12869</identifier>
  <creators>
    <creator>
      <creatorName>Heath, Paul R.</creatorName>
      <givenName>Paul R.</givenName>
      <familyName>Heath</familyName>
      <affiliation>Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield S10 2HQ, S Yorkshire, England</affiliation>
    </creator>
    <creator>
      <creatorName>Kirby, Janine</creatorName>
      <givenName>Janine</givenName>
      <familyName>Kirby</familyName>
      <affiliation>Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield S10 2HQ, S Yorkshire, England</affiliation>
    </creator>
    <creator>
      <creatorName>Shaw, Pamela J.</creatorName>
      <givenName>Pamela J.</givenName>
      <familyName>Shaw</familyName>
      <affiliation>Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield S10 2HQ, S Yorkshire, England</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Investigating Cell Death Mechanisms In Amyotrophic Lateral Sclerosis Using Transcriptomics</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/12869</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3389/fncel.2013.00259</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by degeneration and loss of upper and lower motor neurons from the motor cortex, brainstem and spinal cord although evidence is suggesting that there is further involvement of other cell types in the surrounding tissue. Transcriptomic analysis by gene expression profiling using microarray technology has enabled the determination of patterns of cell death in the degenerating tissues. This work has examined gene expression at the level of the tissue and individual cell types in both sporadic and familial forms of the disease. In addition, further studies have examined the differential vulnerability of neuronal cells in different regions of the central nervous system. Model systems have also provided further information to help unravel the mechanisms that lead to death of the motor neurons in disease and also provided novel insights. In this review we shall describe the methods that have been used in these investigations and describe how they have contributed to our knowledge of the cell death mechanisms in ALS.</description>
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