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Synthesis of 5-(7 '-indolyl)oxazoles and 2,5-di-(7 '-indolyl)oxazoles

Kandemir, Hakan; Wood, Kasey; Kumar, Naresh; Black, David StC


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        "affiliation": "Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia", 
        "name": "Wood, Kasey"
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        "affiliation": "Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia", 
        "name": "Kumar, Naresh"
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        "affiliation": "Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia", 
        "name": "Black, David StC"
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    "description": "The synthesis of 7-aminoacetylindoles was achieved via the hydrogenation of 7-acylcyanides, which were produced through the oxidation of indole-7-cyanohydrin silylether intermediates. 7-Oxotryptamines were subsequently converted into 5-(7'-indolyl)oxazoles by reaction with acetic anhydride followed by phosphoryl chloride, and to 2,5-di-(7'-indolyl)oxazoles by reaction with 7-trichloroacetylindoles followed by phosphoryl chloride. (c) 2013 Elsevier Ltd. All rights reserved.", 
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