1 Ocak 2013 Dergi makalesi Açık Erişim

Kalkan, S.; Oransay, K.; Bal, I. B.; Ertunc, M.; Sara, Y.; Iskit, A. B.

Citation Style Language JSON

{
  "DOI": "10.1177/0960327112455670", 
  "abstract": "We investigated the role of adenosine receptors in amitriptyline-induced cardiac action potential (AP) changes in isolated rat atria. In the first group, APs were recorded after cumulative addition of amitriptyline (1 mu M, 10 mu M and 50 mu M). In other groups, each atrium was incubated with selective adenosine A(1) antagonist (8-cyclopentyl-1,3-dipropylxanthine (DPCPX), 10(-4) M) or selective adenosine A(2a) receptor antagonist (8-(3-chlorostyryl) caffeine, 10(-5) M) before amitriptyline administration. Resting membrane potential, AP amplitude (APA), AP duration at 50% and 80% of repolarization (APD(50) and APD(80), respectively), and the maximum rise and decay slopes of AP were recorded. Amitriptyline (50 mu M) prolonged the APD(50) and APD(80) (p < 0.001) and the maximum rise slope of AP was reduced by amitriptyline (p < 0.0001). Amitriptyline reduced maximum decay slope of AP only at 50 mu M (p < 0.01). DPCPX significantly decreased the 50-mu M amitriptyline-induced APD(50) and APD(80) prolongation (p < 0.001). DPCPX significantly prevented the effects of amitriptyline (1 mu M and 50 mu M) on maximum rise slope of AP (p < 0.05). DPCPX significantly prevented the amitriptyline-induced (50 mu M) reduction in maximum decay slope of AP (p < 0.001). The selective adenosine A(1) receptor antagonist prevented the electrophysiological effects of amitriptyline on atrial AP. A(1) receptor stimulation may be responsible for the cardiovascular toxic effects produced by amitriptyline.", 
  "author": [
    {
      "family": "Kalkan", 
      "given": " S."
    }, 
    {
      "family": "Oransay", 
      "given": " K."
    }, 
    {
      "family": "Bal", 
      "given": " I. B."
    }, 
    {
      "family": "Ertunc", 
      "given": " M."
    }, 
    {
      "family": "Sara", 
      "given": " Y."
    }, 
    {
      "family": "Iskit", 
      "given": " A. B."
    }
  ], 
  "container_title": "HUMAN & EXPERIMENTAL TOXICOLOGY", 
  "id": "12335", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2013, 
        1, 
        1
      ]
    ]
  }, 
  "page": "62-69", 
  "title": "The role of adenosine receptors on amitriptyline-induced electrophysiological changes on rat atrium", 
  "type": "article-journal", 
  "volume": "32"
}