1 Ocak 2013 Dergi makalesi Açık Erişim

Sidir, Isa; Sidir, Yadigar Gulseven; Berber, Halil

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/12029</identifier>
  <creators>
    <creator>
      <creatorName>Sidir, Isa</creatorName>
      <givenName>Isa</givenName>
      <familyName>Sidir</familyName>
      <affiliation>Bitlis Eren Univ, Fac Arts &amp; Sci, Dept Phys, TR-13000 Bitlis, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sidir, Yadigar Gulseven</creatorName>
      <givenName>Yadigar Gulseven</givenName>
      <familyName>Sidir</familyName>
      <affiliation>Bitlis Eren Univ, Fac Arts &amp; Sci, Dept Phys, TR-13000 Bitlis, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Berber, Halil</creatorName>
      <givenName>Halil</givenName>
      <familyName>Berber</familyName>
      <affiliation>Anadolu Univ, Fac Sci, Dept Chem, TR-26470 Eskisehir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Acidity Constant Determination Of Novel Drug Precursor Benzothiazolon Derivatives Including Acyl And Piperazine Moieties</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/12029</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.saa.2013.03.071</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In this study, protonation and deprotonation behaviors of eight new drug precursor benzothiazolon derivatives in all of acidic and basic scale (super acidic, pH, super basic regions) are analyzed by using UV-visible spectrophotometric technique. Acidity constants (pK(a)), elucidation of the structure and protonation mechanisms of the studied molecules are obtained. Substituent effect on acidity constant values is discussed. These molecules are protonated from oxygen atom of acetamide group in the keto form. The protonation is found to be considerably contributed by the keto form. (C) 2013 Elsevier B.V. All rights reserved.</description>
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