1 Ocak 2020 Dergi makalesi Açık Erişim

Haidar, Mohammad Karim; Timur, Selin Seda; Kazanci, Atilla; Turkoglu, Omer Faruk; Gursoy, R. Neslihan; Nemutlu, Emirhan; Sargon, Mustafa Fevzi; Bodur, Ebru; Gok, Muslum; Ulubayram, Kezban; Oner, Levent; Eroglu, Hakan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/11583</identifier>
  <creators>
    <creator>
      <creatorName>Haidar, Mohammad Karim</creatorName>
      <givenName>Mohammad Karim</givenName>
      <familyName>Haidar</familyName>
    </creator>
    <creator>
      <creatorName>Timur, Selin Seda</creatorName>
      <givenName>Selin Seda</givenName>
      <familyName>Timur</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kazanci, Atilla</creatorName>
      <givenName>Atilla</givenName>
      <familyName>Kazanci</familyName>
      <affiliation>Ankara Yildirim Beyazit Univ, Dept Neurosurg, Fac Med, TR-06810 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Turkoglu, Omer Faruk</creatorName>
      <givenName>Omer Faruk</givenName>
      <familyName>Turkoglu</familyName>
      <affiliation>Turkish Republ Minist Hlth, Dept Neurosurg, City Hosp, TR-06810 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gursoy, R. Neslihan</creatorName>
      <givenName>R. Neslihan</givenName>
      <familyName>Gursoy</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nemutlu, Emirhan</creatorName>
      <givenName>Emirhan</givenName>
      <familyName>Nemutlu</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Analyt Chem, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sargon, Mustafa Fevzi</creatorName>
      <givenName>Mustafa Fevzi</givenName>
      <familyName>Sargon</familyName>
      <affiliation>Atilim Univ, Sch Med, Dept Anat, TR-06830 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bodur, Ebru</creatorName>
      <givenName>Ebru</givenName>
      <familyName>Bodur</familyName>
      <affiliation>Hacettepe Univ, Fac Med, Dept Biochem, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gok, Muslum</creatorName>
      <givenName>Muslum</givenName>
      <familyName>Gok</familyName>
      <affiliation>Hacettepe Univ, Fac Med, Dept Biochem, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ulubayram, Kezban</creatorName>
      <givenName>Kezban</givenName>
      <familyName>Ulubayram</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Basic Pharmaceut Sci, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oner, Levent</creatorName>
      <givenName>Levent</givenName>
      <familyName>Oner</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Eroglu, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Eroglu</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Composite Nanofibers Incorporating Alpha Lipoic Acid And Atorvastatin Provide Neuroprotection After Peripheral Nerve Injury In Rats</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/11583</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ejpb.2020.05.032</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Despite the new treatment strategies within the last 30 years, peripheral nerve injury (PNI) is still a worldwide clinical problem. The incidence rate of PNIs is 1 in 1000 individuals per year. In this study, we designed a composite nanoplatform for dual therapy in peripheral nerve injury and investigated the in-vivo efficacy in rat sciatic nerve crush injury model. Alpha-lipoic acid (ALA) was loaded into poly lactic-co-glycolic acid (PLGA) electrospun nanofibers which would release the drug in a faster manner and atorvastatin (ATR) loaded chitosan (CH) nanoparticles were embedded into PLGA nanofibers to provide sustained release. Sciatic nerve crush was generated via Yasargil aneurism clip with a holding force of 50 g/cm(2). Nanofiber formulations were administered to the injured nerve immediately after trauma. Functional recovery of operated rat hind limb was evaluated using the sciatic functional index (SFI), extensor postural thrust (EPT), withdrawal reflex latency (WRL) and Basso, Beattie, and Bresnahan (BBB) test up to one month in the post-operative period at different time intervals. In addition to functional recovery assessments, ultrastructural and biochemical analyses were carried out on regenerated nerve fibers. L-929 mouse fibroblast cell line and B35 neuroblastoma cell line were used to investigate the cytotoxicity of nanofibers before in-vivo experiments. The neuroprotection potential of these novel nanocomposite fiber formulations has been demonstrated after local implantation of composite nanofiber sheets incorporating ALA and ATR, which contributed to the recovery of the motor and sensory function and nerve regeneration in a rat sciatic nerve crush injury model.</description>
  </descriptions>
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