1 Ocak 2020 Dergi makalesi Açık Erişim

Senkuytu, Elif; Kizilkaya, Perihan; Olcer, Zehra; Pala, Ugur; Davarci, Derya; Zorlu, Yunus; Erdogan, Huriye; Ciftci, Gonul Yenilmez

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/11453</identifier>
  <creators>
    <creator>
      <creatorName>Senkuytu, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Senkuytu</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kizilkaya, Perihan</creatorName>
      <givenName>Perihan</givenName>
      <familyName>Kizilkaya</familyName>
    </creator>
    <creator>
      <creatorName>Olcer, Zehra</creatorName>
      <givenName>Zehra</givenName>
      <familyName>Olcer</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Pala, Ugur</creatorName>
      <givenName>Ugur</givenName>
      <familyName>Pala</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Davarci, Derya</creatorName>
      <givenName>Derya</givenName>
      <familyName>Davarci</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Zorlu, Yunus</creatorName>
      <givenName>Yunus</givenName>
      <familyName>Zorlu</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erdogan, Huriye</creatorName>
      <givenName>Huriye</givenName>
      <familyName>Erdogan</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ciftci, Gonul Yenilmez</creatorName>
      <givenName>Gonul Yenilmez</givenName>
      <familyName>Ciftci</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Electrophoresis And Biosensor-Based Dna Interaction Analysis Of The First Paraben Derivatives Of Spermine-Bridged Cyclotriphosphazenes</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/11453</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/acs.inorgchem.9b03031</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Cancer is the uncontrolled growth of abnormal cells via malignant cell division and rapid DNA replication. While DNA damaging molecules can cause cancer, their role as anticancer drugs are very significant. For this purpose, the novel series of paraben substituted spermine bridged(dispirobino) cyclotriphosphazene compounds 2-6 were synthesized for the first time, and their structures were characterized by various spectroscopic techniques. The solid-state structures and geometries of compounds 2-6 were determined using single-crystal X-ray structural analysis. In addition, it was confirmed by TGA that all compounds 1-6 showed high thermal stability. Two methods were used in order to investigate DNA interaction properties of the targeted molecules. While biosensor-based screening test that measures DNA hybridization efficiency on a biochip surface, the agarose gel electrophoresis method examines the effect of compounds on plasmid DNA structure. The results collected from the automated biosensor device and agarose gel electrophoresis have indicated that compounds 1, 5, and 6 showed higher DNA damage than the compounds 2-4. According to the biosensor results, compounds 1, 5, and 6 showed 85%, 69%, and 77% activity, respectively.</description>
  </descriptions>
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