1 Ocak 2016 Dergi makalesi Açık Erişim

Kiyma, Zekeriya; Kose, Mehmet; Atli, Mehmet Osman; Ozel, Caglayan; Hitit, Mustafa; Sen, Gonca; Kaya, Muhammet; Kaya, Mehmet Salih; Kurar, Ercan; Kayis, Seyit Ali; Guzeloglu, Aydin

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/111656</identifier>
  <creators>
    <creator>
      <creatorName>Kiyma, Zekeriya</creatorName>
      <givenName>Zekeriya</givenName>
      <familyName>Kiyma</familyName>
      <affiliation>Eskisehir Osmangazi Univ, Fac Agr, Dept Anim Sci, TR-26160 Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kose, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Kose</familyName>
      <affiliation>Dicle Univ, Fac Vet Med, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Atli, Mehmet Osman</creatorName>
      <givenName>Mehmet Osman</givenName>
      <familyName>Atli</familyName>
      <affiliation>Dicle Univ, Fac Vet Med, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozel, Caglayan</creatorName>
      <givenName>Caglayan</givenName>
      <familyName>Ozel</familyName>
      <affiliation>Selcuk Univ, Fac Vet Med, TR-42003 Konya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hitit, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Hitit</familyName>
      <affiliation>Selcuk Univ, Fac Vet Med, TR-42003 Konya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sen, Gonca</creatorName>
      <givenName>Gonca</givenName>
      <familyName>Sen</familyName>
      <affiliation>Selcuk Univ, Fac Vet Med, TR-42003 Konya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kaya, Muhammet</creatorName>
      <givenName>Muhammet</givenName>
      <familyName>Kaya</familyName>
      <affiliation>Eskisehir Osmangazi Univ, Fac Agr, Dept Anim Sci, TR-26160 Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kaya, Mehmet Salih</creatorName>
      <givenName>Mehmet Salih</givenName>
      <familyName>Kaya</familyName>
      <affiliation>Dicle Univ, Fac Vet Med, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kurar, Ercan</creatorName>
      <givenName>Ercan</givenName>
      <familyName>Kurar</familyName>
      <affiliation>Necmettin Erbakan Univ, Meram Fac Med, TR-42080 Konya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kayis, Seyit Ali</creatorName>
      <givenName>Seyit Ali</givenName>
      <familyName>Kayis</familyName>
      <affiliation>Karabuk Univ, Fac Med, TR-78000 Karabuk, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guzeloglu, Aydin</creatorName>
      <givenName>Aydin</givenName>
      <familyName>Guzeloglu</familyName>
      <affiliation>Selcuk Univ, Fac Vet Med, TR-42003 Konya, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Investigation Of Interferon-Tau Stimulated Genes (Isgs) Simultaneously In The Endometrium, Corpus Luteum (Cl) And Peripheral Blood Leukocytes (Pbls) In The Preluteolytic Stage Of Early Pregnancy In Ewes</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/111656</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.smallrumres.2016.05.007</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The aim of the present study was to investigate the expression profiles of Interferon-tau (IFN-T) stimulated genes (ISGs) at the mid-luteal stage of the cycle (on day 13) in the uterine endometrium and extra-uterine tissues, such as the corpus luteum (CL), and in the peripheral blood leukocytes (PBLs) of pregnant and non -pregnant ewes, The objective was to evaluate the possibility of using the regulation of ISG expression in PBLs as a possible early pregnancy indicator in ruminants. For this purpose, multiparous ewes were synchronized and either allowed to mate (pregnancy group) or detected in estrus (cyclic group; day 0). The ewes were slaughtered on day 13, and the PBLs, endometrium and luteal tissues were collected. Total RNA was isolated from eight cyclic and eight pregnant ewes, and qPCR was employed to detect the steady state levels of Interferon -stimulated gene 15 (ISG15), Myxovirus (influenza virus) resistance 1 (Mxl) and Receptor transporter protein 4 (RTP4) mRNAs. The expressions of ISG15, Mxl and RTP4 were detected in the endometrium, CL and PBLs on day 13 of the estrous cycle and pregnancy. The expressions of these ISGs were upregulated only in the endometrium of pregnant ewes compared to non-pregnant ewes, but this stimulation was not observed in the CL and PBLs. The results suggest that the embryo stimulates ISGs only in the endometrium, and the effects are not evident in the extra-uterine tissues on day 13 of pregnancy. This study suggests that the measurement of the ISG expression in the PBLs is not a reliable detection method of early pregnancy in ewes, which are in the preluteolytic stage of early pregnancy. (C) 2016 Elsevier B.V. All rights reserved.</description>
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