1 Ocak 1998 Dergi makalesi Açık Erişim

Haliloglu, T; Bahar, I

Dublin Core

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  <dc:creator>Haliloglu, T</dc:creator>
  <dc:creator>Bahar, I</dc:creator>
  <dc:date>1998-01-01</dc:date>
  <dc:description>A coarse-grained dynamic Monte Carlo method is proposed for investigating the conformational dynamics of proteins, Each residue is represented by two interaction sites, one at the alpha-carbon, and the other on the amino acid sidechain, Geometry and energy parameters extracted from databank structures are used, The method is applied to the crystal structure of apomyoglobin (apo-Mb). Equilibrium and dynamic properties of ape-Mb are characterized within computation times one order of magnitude shorter than conventional molecular dynamics (MD) simulations. The calculated rms fluctuations in alpha-carbons are in good agreement with crystallographic temperature factors. Regions exhibiting enhanced conformational mobilities are identified. Among the loops connecting the eight helices A to H, the loop CD undergoes the fastest motions, leading to partial unwinding of helix D. Helix G is the most stable helix on the basis of the kinetic stability of dihedral angles, followed by the respective helices A, E, H, and B. These results, in agreement with H/D exchange and two-dimensional NMR experiments, as well as with MD simulations, lend support to the use of the proposed approach as an efficient, yet physically plausible, means of characterizing protein conformational dynamics. (C) 1998 Wiley-Liss, Inc.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/103233</dc:identifier>
  <dc:identifier>oai:zenodo.org:103233</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>PROTEINS-STRUCTURE FUNCTION AND GENETICS 31(3) 271-281</dc:source>
  <dc:title>Coarse-grained simulations of conformational dynamics of proteins: Application to apomyoglobin</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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