Dergi makalesi Açık Erişim
Aral, Kubra; Berdeli, Eynar; Cooper, Paul Roy; Milward, Michael Robert; Kapila, Yvonne; Unal, Beyza Karadede; Aral, Cuneyt Asim; Berdeli, Afig
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Differential expression of inflammasome regulatory transcripts in periodontal disease</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">JOURNAL OF PERIODONTOLOGY</subfield> <subfield code="v">91</subfield> <subfield code="n">5</subfield> <subfield code="c">606-616</subfield> </datafield> <controlfield tag="001">10263</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Background The inflammasome modulates the release of key proinflammatory cytokines associated with periodontal disease pathogenesis. The aim of this study was to evaluate the expression of proteins that regulate the inflammasome, namely pyrin domain-only proteins (POPs), caspase activation recruitment domain (CARD)-only proteins, and tripartite motif-containing (TRIM) proteins, in periodontal diseases. Methods A total of 68 participants (34 males and 34 females) were divided into four groups, including periodontal health (H), gingivitis (G), chronic periodontitis (CP), and aggressive periodontitis (AgP) based on clinical parameters. Gingival tissue samples were obtained from all participants for reverse transcription polymerase chain reaction (RT-PCR)-based gene expression analyses of molecules that regulate the inflammasome, including apoptosis-associated speck-like protein (ASC) containing CARD, caspase-1, interleukin-1 beta (IL-1 beta), interleukin-18 (IL-18), nucleotide-binding domain, leucine rich family (NLR) pyrin domain containing 3 (NLRP3), NLR family pyrin domain containing 2 (NLRP2), AIM2 (absent in melanoma 2), POP1, POP2, CARD16, CARD18, TRIM16, and TRIM20 by RT-PCR. Results NLRP3 and IL-1 beta were upregulated in the G, CP, and AgP groups compared with group H (P &lt; 0.05). AIM2 was downregulated in the CP group compared with the H, G, and AgP groups (P &lt; 0.05). TRIM20, TRIM16, and CARD18 were downregulated in the G, CP, and AgP groups compared with the H group (P &lt; 0.05). POP1 and POP2 were downregulated in the CP and AgP, and AgP and G groups, respectively (P &lt; 0.05). Conclusion Active periodontal disease may result in downregulation of inflammasome regulators that may increase the activity of NLRP3 and IL-1 beta in periodontal disease.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Izmir Katip Celebi Univ, Fac Dent, Izmir, Turkey</subfield> <subfield code="a">Berdeli, Eynar</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Birmingham, Sch Dent, Birmingham, W Midlands, England</subfield> <subfield code="a">Cooper, Paul Roy</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Birmingham, Sch Dent, Birmingham, W Midlands, England</subfield> <subfield code="a">Milward, Michael Robert</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Calif San Francisco, Sch Dent, San Francisco, CA USA</subfield> <subfield code="a">Kapila, Yvonne</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Izmir Katip Celebi Univ, Fac Dent, Izmir, Turkey</subfield> <subfield code="a">Unal, Beyza Karadede</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Inonu Univ, Fac Dent, Malatya, Turkey</subfield> <subfield code="a">Aral, Cuneyt Asim</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ege Univ, Fac Med, Mol Med Lab, Izmir, Turkey</subfield> <subfield code="a">Berdeli, Afig</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Univ Birmingham, Sch Dent, Oral Biol, 5 Mill Pool Way, Birmingham B5 7EG, W Midlands, England</subfield> <subfield code="a">Aral, Kubra</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2020-01-01</subfield> </datafield> <controlfield tag="005">20210315072428.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:10263</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:a56f50c0cc5238821de661d8f88ff653</subfield> <subfield code="s">230</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/10263/files/bib-06b214ea-d8c1-4500-8899-f295b0f2f8f8.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1002/JPER.19-0222</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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