1 Ocak 1998 Dergi makalesi Açık Erişim

Guzey, M; Sattler, C; DeLuca, HF

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/101095</identifier>
  <creators>
    <creator>
      <creatorName>Guzey, M</creatorName>
      <givenName>M</givenName>
      <familyName>Guzey</familyName>
    </creator>
    <creator>
      <creatorName>Sattler, C</creatorName>
      <givenName>C</givenName>
      <familyName>Sattler</familyName>
    </creator>
    <creator>
      <creatorName>DeLuca, HF</creatorName>
      <givenName>HF</givenName>
      <familyName>DeLuca</familyName>
    </creator>
  </creators>
  <titles>
    <title>Combinational Effects Of Vitamin D-3 And Retinoic Acid (All Trans And 9 Cis) On Proliferation, Differentiation, And Programmed Cell Death In Two Small Cell Lung Carcinoma Cell Lines</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>1998</publicationYear>
  <dates>
    <date dateType="Issued">1998-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
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    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/101095</alternateIdentifier>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.81043/aperta.101094</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.81043/aperta.101095</relatedIdentifier>
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  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
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  <descriptions>
    <description descriptionType="Abstract">The effects of a combination of vitamin D-3 [1,25(OH)(2)D-3] and retinoic acid (RA) on proliferation, differentiation, and apoptosis of the human small cell lung carcinoma (SCLC) cell lines NCI-H82 and NCI-H209 were evaluated. Cell proliferation was inhibited by 1,25(OH)(2)D-3 and RA alone. The combination of 1,25(OH)(2)D-3 and the cis form of retinoic acid resulted in an additive decrease in cell proliferation and the induction of apoptosis in various concentrations. Moreover, H-3-thymidine incorporation was inhibited and the number of viable cells was decreased. The characteristics of the apoptotic cells were examined and confirmed by morphologic analysis, light and electron microscopy, and fluorescence detection. It was concluded that 1,25(OH)(2)D-3 and RA exert additive effects on the inhibition of proliferation and the induction of apoptosis in both the NCI-H82 and the NCI-H209 SCLC cell lines. This finding has important implications for the use of retinoids and 1,25(OH)(2)D-3 in cancer prevention and in the therapy of small cell lung carcinoma. (C) 1998 Academic Press.</description>
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