Published January 1, 2008
| Version v1
Journal article
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Hydrophobically modified low molecular weight chitosans as efficient and nontoxic gene delivery vectors
Creators
- 1. Univ Strasbourg 1, Fac Pharm, Inst Gilbert Laustriat,Dept Pharmacol & Physicoch, Equipe Photophys Interact Biomol,UMR 7175, F-67401 Illkirch Graffenstaden, France
- 2. Russian Acad Sci, A Nesmeyanov Inst Elemento Organic Cpds INEOS, Moscow, Russia
- 3. Russian Acad Med Sci, Influenza Res Inst, St Petersburg, Russia
Description
Background Chitosan derivatives are potential candidates for gene delivery because they are biocompatible and low toxic. However, their use has been limited by their moderate transfection efficiency and the rather large sizes of DNA complexes with high molecular weight chitosans. To circumvent, these limitations, we used low molecular weight (approximately 5 kDa) chitosans grafted at 3 and 18 mol% with N-/2(3)-(dodec-2-enyl)succinoyl groups (HM-LMW-ch) that exhibit surfactant-like properties.
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