Published January 1, 2020
| Version v1
Journal article
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Self-reporting heavy atom-free photodynamic therapy agents
Creators
- 1. Selcuk Univ, Dept Nanotechnol & Adv Mat, TR-42250 Konya, Turkey
- 2. Konya Food & Agr Univ, Res & Dev Ctr Diagnost Kits KIT ARGEM, TR-42080 Konya, Turkey
- 3. Uskudar Univ, Dept Mol Biol & Genet, TR-39662 Istanbul, Turkey
Description
Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of O-1(2) generation without any significant change in photodynamic activity.
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