Published January 1, 2020 | Version v1
Journal article Open

Lack of hotspot mutations other than TP53 R249S in aflatoxin B1 associated hepatocellular carcinoma

  • 1. Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Med Biol, Kayisdagi Cad 32, TR-34752 Istanbul, Turkey
  • 2. Acibadem Mehmet Ali Aydinlar Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Istanbul, Turkey

Description

Objective: Despite the recent advances in diagnosis and treatment of hepatocellular carcinoma (HCC), it is still a major health problem. Therefore, understanding the molecular mechanism is very important. Our aim is to investigate the molecular basis of aflatoxin B1 (AFB1) induced HCC other than the hotspot TP53 p.Arg249Ser (c.747G>T) (R249S) mutation.

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