Yayınlanmış 1 Ocak 2019 | Sürüm v1
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A Proteomic Analysis of Mitochondrial Complex III Inhibition in SH-SY5Y Human Neuroblastoma Cell Line

Oluşturanlar

  • 1. Rutgers State Univ, New Jersey Med Sch, Reynolds Family Spine Lab, Dept Neurol Surg, Newark, NJ 07103 USA
  • 2. Acibadem Labmed, Res & Dev Ctr, Med Labs, Istanbul, Turkey
  • 3. TUBITAK, Marmara Res Ctr, Genet Engn & Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey
  • 4. Koc Univ, Res Ctr Translat Med, Sch Med, Istanbul, Turkey
  • 5. Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Med Biochem, Istanbul, Turkey

Açıklama

Background and Objective: Antimycin A (AntA) is a potent Electron Transport System (ETS) inhibitor exerting its effect through inhibiting the transfer of the electrons by binding to the quinone reduction site of the cytochrome bcl complex (Complex III), which is known to be impaired in Huntington's Disease (HD). The current studies were undertaken to investigate the effect of complex III inhibition in the SH-SY5Y cell line to delineate the molecular and cellular processes, which may play a role in the pathogenesis of HD.

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