Yayınlanmış 1 Ocak 2014 | Sürüm v1
Dergi makalesi Açık

Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair

  • 1. Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey
  • 2. TUBITAK BILGEM UEKAE, Gebze, Kocaeli, Turkey
  • 3. TUBITAK MAM GEBI, Gebze, Kocaeli, Turkey
  • 4. Bilkent Univ, Fac Engn, Dept Comp Engn, TR-06800 Ankara, Turkey

Açıklama

Background Human de novo single-nucleotide variation (SNV) rate is estimated to range between 0.82-1.70x10(-8) mutations per base per generation. However, contribution of early postzygotic mutations to the overall human de novo SNV rate is unknown.

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