Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair

Dal, Guelsah M.; Erguner, Bekir; Sagiroglu, Mahmut S.; Yuksel, Bayram; Onat, Onur Emre; Alkan, Can; Ozcelik, Tayfun

doi:10.1136/jmedgenet-2013-102197

Published January 1, 2014 | Version v1

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Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair

1. Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey
2. TUBITAK BILGEM UEKAE, Gebze, Kocaeli, Turkey
3. TUBITAK MAM GEBI, Gebze, Kocaeli, Turkey
4. Bilkent Univ, Fac Engn, Dept Comp Engn, TR-06800 Ankara, Turkey

Background Human de novo single-nucleotide variation (SNV) rate is estimated to range between 0.82-1.70x10(-8) mutations per base per generation. However, contribution of early postzygotic mutations to the overall human de novo SNV rate is unknown.

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March 16, 2021

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JOURNAL OF MEDICAL GENETICS, 51(7), 455-459, 2014.

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Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair

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Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair

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