Published January 1, 2017
| Version v1
Journal article
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Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
Creators
- 1. Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey
- 2. TUBITAK, UME, Chem Grp Labs, Gebze, Turkey
Description
Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).
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