Yayınlanmış 1 Ocak 2017
| Sürüm v1
Dergi makalesi
Açık
Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
Oluşturanlar
- 1. Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey
- 2. TUBITAK, UME, Chem Grp Labs, Gebze, Turkey
Açıklama
Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).
Dosyalar
bib-48b782f5-5de5-4d10-8c53-00f62e54d2c0.txt
Dosyalar
(252 Bytes)
| Ad | Boyut | Hepisini indir |
|---|---|---|
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md5:9fbf31693ed54cecb6d3755b2fe3dc60
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252 Bytes | Ön İzleme İndir |