Yayınlanmış 1 Ocak 2017 | Sürüm v1
Dergi makalesi Açık

Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents

  • 1. Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey
  • 2. TUBITAK, UME, Chem Grp Labs, Gebze, Turkey

Açıklama

Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).

Dosyalar

bib-48b782f5-5de5-4d10-8c53-00f62e54d2c0.txt

Dosyalar (252 Bytes)

Ad Boyut Hepisini indir
md5:9fbf31693ed54cecb6d3755b2fe3dc60
252 Bytes Ön İzleme İndir