Published January 1, 2017 | Version v1
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Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents

  • 1. Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey
  • 2. TUBITAK, UME, Chem Grp Labs, Gebze, Turkey

Description

Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).

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