Published January 1, 2017
| Version v1
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Biophysical characterization of quaternary pyridinium functionalized polynorbornenes for DNA complexation and their cellular interactions
- 1. TUBITAK Marmara Res Ctr, Genet Engn & Biotechnol Inst, Gebze 21, TR-41470 Gebze, Turkey
Description
Cationic polymers with hydrophobic side chains have gained great interest as DNA carriers since they form a compact complex with negatively charged DNA phosphate groups and interact with the cell membrane. Amphiphilic polyoxanorbornenes with different quaternary alkyl pyridinium side chains with ethyl- p(OPy2) and hexyl unitsp(OPy6) bearing 10 kDa MWT were synthesized by living Ring- Opening Metathesis Polymerization method.
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