Published January 1, 2017
| Version v1
Journal article
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Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents
Creators
- 1. TUBITAK, Marmara Res Ctr, Genet Engn & Biotechnol Inst, Gebze, Kocaeli, Turkey
- 2. Uludag Univ, Fac Arts & Sci, Dept Biol, Bursa, Turkey
- 3. Uludag Univ, Sch Med, Dept Med Biochem, Bursa, Turkey
- 4. Univ Lisbon, Ctr Quim Estrutural, Inst Super Tecn, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal
Description
Background: To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based compounds. Here, three Cu(II)-complexes, Cu(Sal-Gly)(phen), Cu(Sal-Gly)(pheamine), Cu(Sal-Gly)(phepoxy) are characterized for their interaction with DNA, cytotoxicity and mechanism of action.
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