Published January 1, 2017
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Sambulin A and B, non-glycosidic iridoids from Sambucus ebulus, exert significant in vitro anti-inflammatory activity in LPS-induced RAW 264.7 macrophages via inhibition of MAPKs's phosphorylation
Creators
- 1. Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, TR-34755 Istanbul, Turkey
- 2. TUBITAK Natl Metrol Inst, Chem Grp Labs, TR-41470 Gebze, Kocaeli, Turkey
- 3. Yeditepe Univ, Fac Pharm, Dept Pharmacognosy & Phytotherapy, TR-34755 Istanbul, Turkey
Description
Ethnopharmacological relevance: The leaves of Sambucus ebulus L. (Adoxaceae) are widely used in Turkish folk medicine particularly against inflammatory disorders. The fresh leaves after wilted over fire or the poultices prepared are directly applied externally to heal burns, edema, eczema, urticarial and abscess. Two iridoids were recently isolated (sambulin A, sambulin B) from the leaves of S. ebulus.
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