Published January 1, 2018 | Version v1
Journal article Open

Clinical phenotype of hereditary spastic paraplegia due to KIF1C gene mutations across life span

Creators

  • 1. Hacettepe Univ, Inst Child Hlth, Dept Pediat Metab, Ankara, Turkey
  • 2. Hacettepe Univ, Fac Med, Dept Pediat Neurol, Ankara, Turkey
  • 3. Hacettepe Univ, Fac Med, Dept Radiol, Ankara, Turkey
  • 4. TUBITAK, Natl Res Inst Elect & Cryptol, Informat & Informat Secur Res Ctr, Ankara, Turkey
  • 5. Istanbul Univ, Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey
  • 6. Hacettepe Univ, Fac Med, Dept Neurol, Ankara, Turkey
  • 7. Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Genet, Istanbul, Turkey
  • 8. Hacettepe Univ, Fac Med, Dept Pediat Metab, TR-06100 Ankara, Turkey

Description

Hereditary spastic paraplegias (HSPs) are a group of genetic disorders resulting in pyramidal tract impairment, predominantly in lower limbs. KIF1C gene has recently been identified as one of the genetic causes of HSP and associated with pure or complicated HSP. We present three patients with complicated HSP from two unrelated families, who had early onset progressive cerebellar signs and developed pyramidal tract signs during follow-up. Whole exome sequencing in these patients followed by segregation analysis identified novel truncating KIFIC mutations (c.463C> T; p.R155* and c.2478delA; p.A1a828Argfs*13). Neuroimaging findings showed cerebral and upper cervical spinal atrophy, bilateral symmetrical pyramidal tract involvement, and focal cerebral white matter lesions. Patients with KIFIC mutations may present with cerebellar signs and pyramidal findings may emerge later, therefore complicated HSP should be considered in the differential diagnosis of unidentified cases with cerebellar dysfunction. (C) 2018 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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