Published January 1, 2020
| Version v1
Journal article
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A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches
Creators
- 1. Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34668 Istanbul, Turkey
- 2. Atilim Univ, Dept Met & Mat Engn, Fac Engn, TR-06836 Ankara, Turkey
- 3. UCL, Dept Mech Engn, Torrington Pl, London WC1E 7JE, England
- 4. Univ Hertfordshire, Sch Engn & Technol, Mech & Mech Engn Div, Hatfield, Herts, England
Description
Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for infra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.
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