Yayınlanmış 1 Ocak 2012
| Sürüm v1
Dergi makalesi
Açık
Synthesis of Cyclopentapyridine and Thienopyridine Derivatives as Potential Calcium Channel Modulators
Oluşturanlar
- 1. Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
- 2. Osmangazi Univ, Fac Med, Dept Pharmacol, Eskisehir, Turkey
- 3. Univ Zurich, Inst Organ Chem, Zurich, Switzerland
Açıklama
In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.
Dosyalar
bib-94275cd6-d5cc-4f2f-a38b-fe1285bf1265.txt
Dosyalar
(246 Bytes)
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md5:7fb4d677ec8159b45b00b5a77b6ca900
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246 Bytes | Ön İzleme İndir |