Published January 1, 2012
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Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures
Creators
- 1. Hungarian Acad Sci, Inst Biochem, Biol Res Ctr, H-6726 Szeged, Hungary
- 2. Ege Univ, Fac Pharm, Dept Biochem, TR-35100 Izmir, Turkey
- 3. Ege Univ, Fac Pharm, Brain Res Ctr, TR-35100 Izmir, Turkey
Description
It has been known for centuries that exogenous cannabinoids, such as tetrahydrocannabinol have anticonvulsant activity. Recent studies have advanced our understanding of the endogenous cannabinoid system and renewed the interest in cannabinoids as a potential treatment for epilepsy. The endogenous cannabinoid system is rapidly activated after seizure activity but still little is known about the molecular mechanisms underlying the role of the cannabinoid system in epilepsy.
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