Published January 1, 2012
| Version v1
Journal article
Open
Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles
Creators
- 1. Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, UA-79010 Lvov, Ukraine
- 2. Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02094 Kiev, Ukraine
- 3. CNRS MNHN, UMR 7245, Team APE, Natl Museum Nat Hist, F-75005 Paris, France
Description
A series of novel 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles-based molecules have been synthesized and evaluated as potential antitrypanosomal agents. The most active analogue 3b inhibited Trypanosoma brucei brucei and Trypanosoma brucei gambiense with an IC50 of 0.26 and 0.42 mu M, respectively. They could be considered as potent hits for further antitrypanosomal drug discovery efforts. (C) 2012 Elsevier Ltd. All rights reserved.
Files
bib-7ba574e4-cb01-4fe2-9ba8-d60dfc4a767b.txt
Files
(237 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:c2fe9d976d3a53ada54012deed1d948f
|
237 Bytes | Preview Download |