Yayınlanmış 1 Ocak 2012
| Sürüm v1
Dergi makalesi
Açık
In vitro inhibition of polyphenol oxidase by some new diarylureas
Oluşturanlar
- 1. Balikesir Univ, Div Biochem, Dept Chem, TR-10145 Balikesir, Turkey
- 2. Sakarya Univ, Dept Chem, Adapazari, Turkey
Açıklama
A new series of N,N'-diarylureas (1-9) was synthesized. These compounds were investigated as inhibitors of polyphenol oxidase (PPO) which had been purified from banana by an affinity gel comprised of Sepharose 4B-L-tyrosine-p-amino benzoic acid. K-i values for (1), (2), (3), (5), (6), (7) and (8) were determined as 0.285, 17.97, 0.187, 0.108, 0.063, 0.044 and 0.047 mM, respectively. Thus (2) was by far the most effective inhibitor. Interestingly, (4) and (9) behaved as an activator of PPO in this study.
Dosyalar
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Dosyalar
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