Published January 1, 2012
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Xanthones inhibitors of alpha-glucosidase and glycation from Garcinia nobilis
Creators
- 1. Univ Yaounde I, Fac Sci, Dept Organ Chem, Yaounde, Cameroon
- 2. Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
- 3. Tribhuvan Univ, Inst Forestry, Pokhara, Kaski, Nepal
- 4. Univ Bielefeld, Dept Chem Organ & Bioorgan Chem, D-33501 Bielefeld, Germany
Description
One new xanthone, caroxanthone (1) together with six known xanthones, 4-prenyl-2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone (2), smeathxanthone A (3), gartanin (4), euxanthone (5), 8-hydroxycudraxanthone G (6) and morusignin I (7) were isolated from the stem bark of Garcinia nobilis. The structures were determined by 1D- and 2D-NMR techniques. All these compounds were tested for anti-glycation, alpha-glucosidase and alpha-chymotrypsin activities. Some of them exhibited strong to moderate alpha-glucosidase activities, while none of them inhibited alpha-chymotrypsin. Compounds 6 and 7 were found to be modest alpha-glucosidase inhibitors with IC50 values of 76 mu M and 84 mu M, respectively. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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