Yayınlanmış 1 Ocak 2012 | Sürüm v1
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Synthesis of Bishomoinositols and an Entry for Construction of a Substituted 3-Oxabicyclo[3.3.1]nonane Skeleton

  • 1. Sakarya Univ, Dept Chem, TR-54100 Sakarya, Turkey
  • 2. Middle E Tech Univ, Dept Chem, TR-06800 Ankara, Turkey
  • 3. Ataturk Univ, Dept Chem, TR-25240 Erzurum, Turkey

Açıklama

1,3,3a,7a-Tetrahydro-2-benzofuran was used as key compound for the synthesis of various bishomoinositol derivatives. The diene was subjected to an epoxidation reaction for further functionalization of the diene unit. The bisepoxide obtained was submitted to a ring-opening reaction with acid in the presence of water. Various bishomoinositols were synthesized. However, when the reaction was carried out in the presence of acetic anhydride, a substituted 3-oxabicyclo[3.3.1]nonane skeleton was formed. The mechanism of the formation of the products is discussed.

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