Four component one-pot synthesis of novel 7,8-dihydroquinolin-5(1H,4H,6H)-one derivatives containing an ionone unit and in vitro antioxidant activity

A new class of novel 7,8-dihydroquinolin-5-(1H,4H,6H)-one derivatives (5ak) were synthesized by the one-pot four-component condensation of dimedon, a-ionone, ammonium acetate, and benzaldehyde derivatives. The structures were characterized by elemental analysis, IR, 1H-NMR, and 13C NMR spectral studies. All the title compounds were screened for antioxidant properties and some of them found to exhibit potent in vitro antioxidant activity. J. Heterocyclic Chem., (2011).