Published January 1, 2012
| Version v1
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Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives
Creators
- 1. Hacettepe Univ, Fac Med, Dept Med Biochem, TR-06100 Ankara, Turkey
- 2. Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
Description
Objective: Glutathione transferases (GST) are multifunctional enzymes involved in detoxication, drug resistance, cell signaling and apoptosis. The inhibitory effects of novel benzazole derivatives were tested on human GST P1-1 to find new agents for overcoming drug resistance in cancer cells.
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