Published January 1, 2012
| Version v1
Journal article
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The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis
Creators
- 1. Istanbul Tech Univ, Fac Sci & Letters, Dept Chem, TR-34469 Istanbul, Turkey
- 2. Ege Univ, Fac Sci, Dept Biochem, TR-35100 Izmir, Turkey
- 3. Ege Univ, Inst Nucl Sci, TR-35100 Izmir, Turkey
- 4. Adnan Menderes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-09100 Aydin, Turkey
Description
Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via I-125 which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.
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