Published January 1, 2012
| Version v1
Journal article
Open
Catalyst- and Base-Controlled Site-Selective sp2 and sp3 Direct Arylation of 5,7-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine Using Aryl Bromides
Creators
- 1. Univ Orleans, CNRS, UMR 7311, Inst Chim Organ & Analyt, F-45067 Orleans 2, France
- 2. Univ Victor Segalen Bordeaux 2, EA4318 Pharmacochim, UFR Sci Pharmaceut, F-33076 Bordeaux, France
Description
The palladium-catalyzed direct CH arylation of various heterocyclic is now recognized to be the most effective methodology for making aromatic compounds. In this paper, we present a new approach to control the site-selective direct CH arylation of both sp2 and sp3 sites in 5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine by using aryl bromides. The desired compounds were obtained in satisfactory yields. The effects of each reaction parameter including catalyst, base, and solvent were investigated.
Files
bib-03c31767-b3b2-47d0-a4b7-b8cc9bc0d3ba.txt
Files
(310 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:16c464dbc6272ae6719b7fd8601883e8
|
310 Bytes | Preview Download |