Published January 1, 2012
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SYNTHESIS AND IN VITRO ANTIMICROBIAL ACTIVITY OF NOVEL 2-(3-OXO-1,3-DIARYLPROPYLTHIO)ACETIC ACID DERIVATIVES
- 1. Gaziosmanpasa Univ, Dept Chem, Fac Arts & Sci, TR-60250 Tokat, Turkey
- 2. Gaziosmanpasa Univ, Dept Biol, Fac Arts & Sci, TR-60250 Tokat, Turkey
Description
A series of novel 2-(3-oxo-1,3-diarylpropylthio)acetic acid derivatives (3a-l) were prepared by base catalyzed addition of thioglycolic acid to chalcones (1a-l). The antibacterial activities of synthesized compounds were screened against human pathogenic microorganisms by employing the disk-diffusion technique. For the active compounds, also minimum inhibitory concentrations (MICs) were determined.
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