Published January 1, 2012
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Vitamin D receptor gene polymorphisms and haplotypes (Apa I, Bsm I, Fok I, Taq I) in Turkish psoriasis patients
- 1. Pamukkale Univ, Fac Med, Dept Med Biol, Kinikli, Denizli, Turkey
- 2. Pamukkale Univ, Fac Med, Dept Dermatol, Kinikli, Denizli, Turkey
- 3. Dokuz Eylul Univ, Fac Med, Dept Dermatol, Izmir, Turkey
Description
Background: Psoriasis is an inflammatory disease characterized by increased squamous cell proliferation and impaired differentiation. Vitamin D, Calcitriol, and its analogues are successfully used for psoriasis therapy. However, it is unknown why some psoriasis patients are resistant to Vitamin D therapy. Vitamin D mediates its activity by a nuclear receptor. It is suggested that polymorphisms and haplotypes in the VDR gene may explain the differences in response to vitamin D therapy.
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