Published January 1, 2015
| Version v1
Journal article
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Role of ATP-dependent K channels in the effects of erythropoietin in renal ischaemia injury
Creators
- 1. Kocaeli Univ, Sch Med, Dept Gen Surg, TR-41380 Umuttepe, Kocaeli, Turkey
- 2. Ankara Univ, Fac Med, Pathophysiol, TR-06100 Ankara, Turkey
- 3. Yeditepe Univ, Dept Physiol, Fac Med, Istanbul, Turkey
Description
Background & objectives: Erythropoietin (EPO) has cytoprotective and anti-apoptotic effects in pathological conditions, including hypoxia and ischaemia-reperfusion injury. One of the targets to protect against injury is ATP-dependent potassium (KATP) channels. These channels could be involved in EPO induced ischaemic preconditoning like a protective effect. We evaluated the cell cytoprotective effects of EPO in relation to KATP channel activation in the renal tubular cell culture model under hypoxic/normoxic conditions.
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