Published January 1, 2015
| Version v1
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The analgesic effect of apelin-13 and its mechanism of action within the nitric oxide and serotonin pathways
- 1. Univ Inonu, Fac Med, Dept Emergency Med, Malatya, Turkey
- 2. Family Hlth Ctr, Demirkoy, Kirklareli, Turkey
- 3. Univ Inonu, Fac Med, Dept Pharmacol, Malatya, Turkey
- 4. Univ Inonu, Fac Med, Dept Biostat & Med Informat, Malatya, Turkey
- 5. Univ Gaziosmanpasa, Fac Med, Dept Pharmacol, Tokat, Turkey
Description
Background: Apelin has various effects on a lot of systems such as central nervous system and cardiovascular system. This study investigated the possible analgesic effects of apelin-13 using the hot-plate and the tail-flick thermal analgesia tests in rats. We also evaluated the mechanism underlying the analgesic effects of apelin-13 by pretreating with Nw-nitro-L-arginine methyl ester (L-NAME) or ondansetron.
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