Published January 1, 2015
| Version v1
Journal article
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Cultured cells of the blood-brain barrier from apolipoprotein B-100 transgenic mice: effects of oxidized low-density lipoprotein treatment
Creators
- 1. Hungarian Acad Sci, Biol Res Ctr, Inst Biophys, Biol Barriers Res Grp, Szeged, Hungary
- 2. Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, Lab Anim Genet & Mol Neurobiol, H-6720 Szeged, Hungary
- 3. Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, Lab Mol Stress Biol, Szeged, Hungary
- 4. Hungarian Acad Sci, Biol Res Ctr, Lab Funct Gen, Labs Core Facil, Szeged, Hungary
Description
Background: The apolipoprotein B-100 (ApoB-100) transgenic mouse line is a model of human atherosclerosis. Latest findings suggest the importance of ApoB-100 in the development of neurodegenerative diseases and microvascular/perivascular localization of ApoB-100 protein was demonstrated in the cerebral cortex of ApoB-100 transgenic mice. The aim of the study was to characterize cultured brain endothelial cells, pericytes and glial cells from wild-type and ApoB-100 transgenic mice and to study the effect of oxidized low-density lipoprotein (oxLDL) on these cells.
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