Published January 1, 2015
| Version v1
Journal article
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Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment
Creators
- 1. Johns Hopkins Univ, Dept Med, Baltimore, MD 21218 USA
- 2. Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA
- 3. Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA
- 4. Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA
Description
Background: Cell death due to anoikis, necrosis and cell egress from transplantation sites limits functional benefits of cellular cardiomyoplasty. Cell dissociation and suspension, which are a pre-requisite for most cell transplantation studies, lead to depression of cellular metabolism and anoikis, which contribute to low engraftment.
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