Published January 1, 2015 | Version v1
Journal article Open

Resveratrol Stimulates Hydrogen Sulfide (H2S) Formation to Relax Murine Corpus Cavernosum

  • 1. Ege Univ, Fac Pharm, Dept Pharmacol, TR-35100 Izmir, Turkey
  • 2. Aston Univ, Aston Med Sch, Aston Med Res Inst, Birmingham B4 7ET, W Midlands, England

Description

IntroductionResveratrol (RVT) found in red wine protects against erectile dysfunction and relaxes penile tissue (corpus cavernosum) via a nitric oxide (NO) independent pathway. However, the mechanism remains to be elucidated. Hydrogen sulfide (H2S) is a potent vasodilator and neuromodulator generated in corpus cavernosum.

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