Published January 1, 2015
| Version v1
Journal article
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Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice
Creators
- 1. Istanbul Univ, Inst Expt Med Res DETAE, Dept Neurosci, Istanbul, Turkey
- 2. Marmara Univ, Fac Med, Div Pediat Allergy & Immunol, Istanbul, Turkey
- 3. Hellenic Pasteur Inst, Dept Neurobiol, Athens, Greece
- 4. Marmara Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Istanbul, Turkey
Description
Background: Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction (NMJ), mostly associated with acetylcholine receptor (AChR) antibodies. Around 5-10 % of MG patients show antibodies to muscle-specific tyrosine kinase (MuSK). Mesenchymal stem cell (MSC) administration has been shown to ameliorate muscle weakness in the experimental autoimmune myasthenia gravis (EAMG) model induced by AChR immunization.
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